Team 5

Our work provides new insights into the neural control of appetite, both in healthy and diseased brains.

The objective of our team is to understand how food-derived nutritional signals are integrated in the brain, and how the brain will act in turn on eating behaviour and whole body's energy balance. The work is carried out mainly in mice, a model giving an integrated vision of the underlying mechanisms from molecule to behaviour. In vitro cellular models make possible a precise examination of these mechanisms. Specific aspects are also addressed in humans.

Different lines of research are currently being carried out.

1) Plasticity of the neural circuits controlling food intake

Hormonal fluctuations and variations in the nutritional status cause reversible neuronal rearrangement within the neural networks that govern hunger and satiety. We are studying the contribution of these neuronal plasticity processes in the control of food intake. Such ability is impaired during obesity.

2) Maternal diet and metabolic health of offspring.

We have identified vitaminic nutritional factors in breast milk that promote resistance to obesity. We are studying how and where in the brain these factors act.

3) Brain lipid sensing.

Ingested and assimilated nutrients are perceived by the brain. We are studying how brain cells perceive nutritional lipids and what is the impact of such perception. In particular, we aim at elucidating the role of intracellular metabolism of fatty acids within peroxisomes of brain cells on the regulation of feeding behaviour.

4) Taste integration at the cerebral level.

The sweet taste is sometimes poorly perceived in the sick brain during neurodegenerative disease. We study the pathological context of this sensory alteration and its delay during the course of the disease. We also examine the possible links with the hormonal status of individuals.

• Permanents:

  • Pierre Andreoletti, Associate Professeur UBE
    
  • Nathalie Bancod, Technician UBE
    
  • Alexandre Benani, CNRS Research Director
    
  • Mustapha Cherkaoui Malki, Professor UBE
    
  • Frédérique Datiche, Associate Professeur UBE
    
  • Vincent Gigot, Research Scientist CNRS
  • Catherine Gondcaille, Research Scientist UBE
  • Agnès Jacquin-Piques, PU-PH CHU Dijon
  • Norbert Latruffe (Emeritat), Professor  UBE
  • Fabienne Liénard, Research Scientist UBE
  • Laetitia Merle, Associate Professeur UBE
  • Hanane Mottous, Technician UBE
  • Emmanuelle Nedelec, Research Scientist CNRS
  • Bruno Patris, Research Scientist CNRS
  • Vivien Pires (CDD), Technician UBE
  • Stéphane Savary, Professor UBE
  • Doriane Trompier, Associate Professeur UBE
  • Anne Vejux, Associate Professeur UBE

  Non permanents:

  • Manon Perrignon-Sommet, PhD student
  • Tatiana Landré, PhD student
  • Vincent Schneider, PhD student

• Postprandial Hyperglycemia Stimulates Neuroglial Plasticity in Hypothalamic POMC Neurons after a Balanced Meal. Nuzzaci D, Cansell C, Liénard F, Nédélec E, Ben Fradj S, Castel J, Foppen E, Denis R, Grouselle D, Laderrière A, Lemoine A, Mathou A, Tolle V, Heurtaux T, Fioramonti X, Audinat E, Pénicaud L, Nahon JL, Rovère C, Benani A. Cell Rep. 2020 Mar 3;30(9):3067-3078.e5. doi: 10.1016/j.celrep.2020.02.029.  PMID: 32130907

• Evidence for Constitutive Microbiota-Dependent Short-Term Control of Food Intake in Mice: Is There a Link with Inflammation, Oxidative Stress, Endotoxemia, and GLP-1? Ben Fradj S, Nédélec E, Salvi J, Fouesnard M, Huillet M, Pallot G, Cansell C, Sanchez C, Philippe C, Gigot V, Lemoine A, Trompier D, Henry T, Petrilli V, Py BF, Guillou H, Loiseau N, Ellero-Simatos S, Nahon JL, Rovère C, Grober J, Boudry G, Douard V, Benani A. Antioxid Redox Signal. 2022 Aug;37(4-6):349-369. doi: 10.1089/ars.2021.0095. PMID: 35166124

• Dietary fatty acid composition drives neuroinflammation and impaired behavior in obesity. Sanchez C, Colson C, Gautier N, Noser P, Salvi J, Villet M, Fleuriot L, Peltier C, Schlich P, Brau F, Sharif A, Altintas A, Amri EZ, Nahon JL, Blondeau N, Benani A, Barrès R, Rovère C. Brain Behav Immun. 2024 Mar;117:330-346. doi: 10.1016/j.bbi.2024.01.216. PMID: 38309640

• Dietary fat exacerbates postprandial hypothalamic inflammation involving glial fibrillary acidic protein-positive cells and microglia in male mice. Cansell C, Stobbe K, Sanchez C, Le Thuc O, Mosser CA, Ben-Fradj S, Leredde J, Lebeaupin C, Debayle D, Fleuriot L, Brau F, Devaux N, Benani A, Audinat E, Blondeau N, Nahon JL, Rovère C. Glia. 2021 Jan;69(1):42-60. doi: 10.1002/glia.23882. PMID: 32659044

• The histone acetyltransferase MOF activates hypothalamic polysialylation to prevent diet-induced obesity in mice. Brenachot X, Rigault C, Nédélec E, Laderrière A, Khanam T, Gouazé A, Chaudy S, Lemoine A, Datiche F, Gascuel J, Pénicaud L, Benani A. Mol Metab. 2014 Jun 13;3(6):619-29. doi: 10.1016/j.molmet.2014.05.006. PMID: 25161885

• Hypothalamic eIF2α signaling regulates food intake. Maurin AC, Benani A, Lorsignol A, Brenachot X, Parry L, Carraro V, Guissard C, Averous J, Jousse C, Bruhat A, Chaveroux C, B'chir W, Muranishi Y, Ron D, Pénicaud L, Fafournoux P. Cell Rep. 2014 Feb 13;6(3):438-44. doi: 10.1016/j.celrep.2014.01.006. PMID: 24485657

• Peroxisomal defects in microglial cells induce a disease-associated microglial signature. Raas Q, Tawbeh A, Tahri-Joutey M, Gondcaille C, Keime C, Kaiser R, Trompier D, Nasser B, Leoni V, Bellanger E, Boussand M, Hamon Y, Benani A, Di Cara F, Truntzer C, Cherkaoui-Malki M, Andreoletti P, Savary S. Front Mol Neurosci. 2023 Apr 17;16:1170313. doi: 10.3389/fnmol.2023.1170313. PMID: 37138705

• Two Argan Oil Phytosterols, Schottenol and Spinasterol, Attenuate Oxidative Stress and Restore LPS-Dysregulated Peroxisomal Functions in Acox1-/- and Wild-Type BV-2 Microglial Cells. Essadek S, Gondcaille C, Savary S, Samadi M, Vamecq J, Lizard G, El Kebbaj R, Latruffe N, Benani A, Nasser B, Cherkaoui-Malki M, Andreoletti P. Antioxidants (Basel). 2023 Jan 11;12(1):168. doi: 10.3390/antiox12010168. PMID: 36671029

• Changes in Taste Perception in Patients with Minor and Major Cognitive Impairment Linked to Alzheimer's Disease Recorded by Gustatory Evoked Potentials. El Kadiri W, Perrignon-Sommet M, Delpont B, Graber M, Mohr S, Mouillot T, Devilliers H, Grall S, Lienard F, Georges M, Brindisi MC, Brondel L, Bejot Y, Leloup C, Jacquin-Piques A. J Alzheimers Dis. 2023;96(4):1593-1607. doi: 10.3233/JAD-230270. PMID: 38007646

• Prolonged latency of the gustatory evoked potentials for sucrose solution in subjects living with obesity compared with normal-weight subjects. Mouillot T, Brindisi MC, Gauthier C, Barthet S, Quere C, Litime D, Perrignon-Sommet M, Grall S, Lienard F, Fenech C, Devilliers H, Rouland A, Georges M, Penicaud L, Brondel L, Leloup C, Jacquin-Piques A. Int J Obes (Lond). 2024 Aug 25. doi: 10.1038/s41366-024-01607-2. PMID: 39183345