Stéphane Savary

Scientist
Stéphane Savary

General information

Researcher

Neurofeed - Neurobiology of Feeding behaviours

 stephane.savary@u-bourgogne.fr

    https://cv.hal.science/stephane-savary

orcid : 0000-0002-9237-1727

Job

Professor, University of Burgundy Europe (IUT Dijon)

Formation

Habilitation to supervise researches, 2004
PhD Immunology 1996

Activities

Research theme

During my PhD at the CIML in Marseille, I made significant contributions to the field of ABC transporters, notably through the discovery of the Abca1, Abcb7, Abcd2 and Abcg1 genes. I continued my academic career at IRBI in Tours, where I focused on molecular symbiosis in parasitic wasps and polydnaviruses before embarking on an academic career.
I was recruited as an associate professor at the University of Burgundy in 1998, where I teach biochemistry and molecular biology at the Dijon IUT. I led a research group on peroxisomal ABC transporters and X-linked adrenoleukodystrophy (X-ALD) in the BioPeroxIL laboratory until 2023. Over the years, I have supervised numerous PhD students and became a professor in 2012, taking on various responsibilities within my institution. My research has focused on elucidating the pathogenesis of X-ALD, studying the link between fatty acids and neuroinflammation, exploring pharmacological therapeutic avenues, and conducting structure-function analyses of peroxisomal ABC transporters.
Since 2024, my work has extended to the study of peroxisomal functions in microglia and brain physiology, with particular reference to lipid sensing and feeding behavior. Internationally recognized for my expertise on peroxisomes, I continue to advance the understanding of peroxisomal functions, lipid metabolism, and neuroscience at the CSGA.

Key words

Peroxisomes, fatty acids, neurodegenerative diseases, ABC transporters, microglia

Important publications

Tawbeh A, Gondcaille C, Saih F-E, Raas Q, Loichot D, Hamon Y, Keime C, Benani A, Di Cara F, Cherkaoui-Malki M, Andreoletti P, Savary S Impaired peroxisomal beta-oxidation in microglia triggers oxidative stress and impacts neurons and oligodendrocytes. Front Mol Neurosci 18: 1542938 (2025)

Parsons BD, Medina-Luna D, Scur M, Pinelli M, Chilvers MA, Hamon Y, Ahmed I, Savary S, Makrigiannis AP, Braverman NE, Karakach T, Di Cara F. Deficiency in peroxisomes underlies failures in neonatal hepatic immune cell hematopoiesis and antigen presentation in a severe Zellweger disease model. Cell Reports 43(2): 113744 (2024).

Di Cara, F, Savary S, Kovacs, W, Kim, P, Rachubinski RA. The peroxisome: an up-and-coming organelle in immunometabolism. Trends Cell Biol. 33(1):70-86 (2023).

Tawbeh A, Raas Q, Tahri-Joutey M, Keime C, Kaiser R, Trompier D, Nasser B, Leoni V, Bellenger E, Dessard M, Hamon Y, Benani A, Di Cara F, Cunha Alves T, Berger J, Weinhofer I, Mandard S, Cherkaoui-Malki M, Andreoletti P, Gondcaille C, Savary S. Immune response of BV-2 microglial cells is impacted by peroxisomal beta-oxidation. Frontiers Mol Neurosci 16: 1299314 (2023)

.Raas Q, Tawbeh A, Tahri-Joutey M, Gondcaille C, Keime C, Kaiser R, Trompier D, Nasser B, Leoni V, Bellenger E, Boussand M, Hamon Y, Benani A, Di Cara F, Truntzer C, Cherkaoui-Malki M, Andreoletti P, Savary S. Peroxisomal defects in BV-2 cells: lipid metabolism reprograming and disease-associated microglial signature. Frontiers Mol Neurosci 16:1170313 (2023).

Raas Q, Gondcaille C, Hamon Y, Leoni V, Caccia C, Menetrier F, Lizard G, Trompier D, Savary S. CRISPR/Cas9-mediated knockout of Abcd1 and Abcd2 genes in BV-2 cells: novel microglial models for X-linked Adrenoleukodystrophy. Biochim Biophys Acta - Mol Cell Biol Lipid (2019) 1864(5): 704-714 (2019).

Neurofeed - Neurobiology of Feeding behaviours