Norbert Latruffe

  http://viaf.org/viaf/12947510

Full professor, University of Burgundy

Biochemist, PhD thesis, Post doc

Starting 1998, he lunched a new challenge on the preventing role of resveratrol, a well known phytophenol from grape and wine, against age-related pathologies : cancer, inflammation and cardiovascular. With his collaborators, he was one of the first to explore resveratrol metabolism (2004 BBRC), its pro-apoptotic properties (2004 J Biol Chem), and discovered a new resveratrol signaling pathway through micro RNA’s modulation (2010 Carcinogenesis). He is now interested on Mediterranean diet and Health (2021, Molecules).
He awarded several distinctions (Prize at the 16th Oncology and Molecular Medicine at Rhodes, laureat of the APICIL foundation, Palmes academic award and s.o.). In october 2023 he enter in the Top 2% rank published by Standford University with 40 other colleagues of the University of Burgundy (UB) of the most influent of the world.

Biochemistry, molecular biology, metabolism, lipids, anti-oxidants, inflammation, healthy diet, mitochondria, peroxisomes.

Zhor C, Wafaa L, Kessas K, Ghzaiel I, Zarrouk A, Ksila M, Ghrairi T, Latruffe N, Lizard G, Kharoubi O. Effects of polyphenols and their metabolites on age-related diseases. Biochem Pharmacol. 2023 Aug;214:115674. doi: 10.1016/j.bcp.2023.115674. Epub 2023 Jul 4.PMID: 37414102

Tahri-Joutey M, Andreoletti P, Surapureddi S, Nasser B, Mustapha Cherkaoui-Malki M, Latruffe N. Mechanisms mediating the regulation of peroxisomal fatty acid beta-oxidation by PPARα.  Int J Mol Sci . 2021 Aug 20;22(16):8969. Doi: 10.3390/Ijms22168969

Vervandier-Fasseur D, Latruffe N. The Potential Use of Resveratrol for Cancer Prevention. Molecules. 2019 Dec 9;24(24):4506. doi: 10.3390/molecules24244506. PMID: 31835371

El Kamouni S, El Kebbaj R, Andreoletti P, El Ktaibi A, Rharrassi I, Essamadi A, El Kebbaj MS, Latruffe N, Vamecq J, Nasser B, Cherkaoui-Malki M. Protective Effect of Argan and Olive Oils against LPS-Induced Oxidative Stress and Inflammation in Mice Livers. Int J Mol Sci. 2017 Oct 19;18(10):2181. doi: 10.3390/ijms18102181.

Limagne E, Cottet V, Cotte A, RollotT F, Hamza S, Hillon P, Latruffe N, Delmas D. Potential role of oxidative DNA damage in the impact of PNPLA3 variant (rs 738409 Cin HCC risk, Hepatology. 2014 Sep;60(3):1110-1. doi: 10.1002/hep.27004. Epub 2014 Jul 28

Frazzi R, Valli R, Tamagnini I, Casali B, Latruffe N, Merli F. Resveratrol-mediated apoptosis of Hodgkin lymphoma cells involves SIRT1 inhibition and FOXO3a hyperacetylation. Int J Cancer. 2013 Mar 1;132(5):1013-21. doi: 10.1002/ijc.27748. Epub 2012 Aug 7.

Kaminski J, Lançon A, Aires V, Limagne E, Tili E, Michaille JJ, Latruffe N. Resveratrol initiates the differentiation of mouse skeletal muscle-derived C2C12 myoblasts. Biochem Pharmacol. 2012 Nov 15;84(10):1251-9. doi: 10.1016/j.bcp.2012.08.023. Epub 2012 Sep 5.

Delmas D, Solary E, Latruffe N (2011). Resveratrol: a phytochemical inducer of multiple cell death pathways: apoptosis, autophagy and mitotic catastrophe. Curr Med Chem. 2011;18(8):1100-21. doi: 10.2174/092986711795029708.