Tatiana Landré

PhD Student, UBE (1st year)
Master degree in Cognitive and Behavioural Neurosciences, Sorbonne Université

My research project is about postprandial cerebral inflammatory reaction and its role on eating behaviour during normal and pathological aging. The team showed that a postprandial inflammatory response occurs in the brain and in particular in the hypothalamus: microglial cells become reactive and adopt an inflammatory phenotype. This response is specific to the nutrients and occurs after a high fat meal. The postprandial inflammatory response triggers an adaptive physiological valence promoting satiety. The permanent inflammatory state in aging brain or in Alzheimer's brain could alter this response by exacerbating it or on the contrary by masking it and thus could promote the eating disorders observed in old people or in Alzheimer’s patients. The project will explore the causal links between brain inflammation and eating behaviour, permitting me to reinforce my expertise in the use of mouse model and its metabolic and cognitive characterisation, in the analysis of the food intake, in the exploitation of brain tissues, in immune-labelling and microscopy and in the characterisation of the inflamed state.

At the same time, I will gain teaching experience through my tutorship in physiology at the UFR SVTE.

Feeding Behaviour, Cerebral inflammation, Microglia, Energetic homeostasis, Aging, Alzheimer disease