Catherine Gondcaille
General information
Neurofeed - Neurobiology of Feeding behaviours
Job
Engineer, University of Burgundy - Europe
Activities
Research theme
After several years studying the function of ABCD1-3 fatty acid transporters, localized in the peroxisome membrane, and the consequences of their dysfunction in neurodegenerative diseases of peroxisomal origin, I joined the NeuroFeed team in 2024.
Within this team, I am involved in projects aimed at understanding the neurological basis of eating behavior, in particular by studying the melanocortin system in the context of a high-fat diet. The aim of this in vivo work in mice is to open up perspectives for the prevention and treatment of pathological eating behaviors such as obesity in humans.
As biochemist, I bring my technical expertise in molecular and cellular biology to in vivo and in vitro studies in mice. I train and scientifically co-supervise BTS/BUT, Licence, Master and PhD students on projects.
Key words
High Fat Diet, hypothalamus, POMC neuron, microglia, oligodendrocyte, inflammation, lipid metabolism, peroxisome
Important publications
Raas Q, Saih FE, Gondcaille C, Trompier D, Hamon Y, Leoni V, Caccia C, Nasser B, Jadot M, Ménétrier F, Lizard G, Cherkaoui-Malki M, Andreoletti P, Savary S. A microglial cell model for acyl-CoA oxidase 1 deficiency. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Apr;1864(4):567-576
Raas Q, Gondcaille C, Hamon Y, Leoni V, Caccia C, Ménétrier F, Lizard G, Trompier D, Savary S. CRISPR/Cas9-mediated knockout of Abcd1 and Abcd2 genes in BV-2 cells: novel microglial models for X-linked Adrenoleukodystrophy. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 May;1864(5):704-714.
Tawbeh A, Gondcaille C, Trompier D, Savary S. Peroxisomal ABC Transporters: An Update. Int J Mol Sci. 2021 Jun 5;22(11):6093.
Raas Q, Tawbeh A, Tahri-Joutey M, Gondcaille C, Keime C, Kaiser R, Trompier D, Nasser B, Leoni V, Bellanger E, Boussand M, Hamon Y, Benani A, Di Cara F, Truntzer C, Cherkaoui-Malki M, Andreoletti P, Savary S. Peroxisomal defects in microglial cells induce a disease-associated microglial signature. Front Mol Neurosci. 2023 Apr 17;16:1170313.
Tawbeh A, Raas Q, Tahri-Joutey M, Keime C, Kaiser R, Trompier D, Nasser B, Bellanger E, Dessard M, Hamon Y, Benani A, Di Cara F, Cunha Alves T, Berger J, Weinhofer I, Mandard S, Cherkaoui-Malki M, Andreoletti P, Gondcaille C, Savary S. Immune response of BV-2 microglial cells is impacted by peroxisomal beta-oxidation. Front Mol Neurosci. 2023 Dec 18;16:1299314.