Team PERSING
Research topics
The team's work is dedicated to basic research to unravel the genetic, molecular and cellular mechanisms at the origin of chemoperception using one of the most powerful models in neurogenetics, Drosophila melanogaster. We study various aspects of olfactory and gustatory perception and how this information is processed and integrated in the brain. We are trying to understand the impact of molecules from food on behavior: odors (mainly short fatty acids), bacterial compounds (peptidoglycan), and sugars (glucose). Concerning the central processing of this chemosensory perception, we focus on a family of amino acid transporters (SLC7) and on the interactions between glia and neurons in the primary (antennal lobe) and secondary (mushroom bodies) centers. We also seek to understand how to replace the use of insecticides, which are toxic to the ecosystem, biodiversity and human health, with food odors to protect fruit crops from insect pests. In this context, we are interested in plant-microorganism-insect communication, mainly targeting Drosophila suzukii.
To accomplish our research goals, we use a wide range of techniques from molecular biology, molecular genetics, evolutionary genetics, biochemistry, cell biology, cell and tissue culture, immunohistology, in vivo calcium imaging, neurobiology, neurophysiology, optogenetics, developmental biology, behavioral analysis. We design and develop our own specific tools.
Research topics
Team picture
Team Leader
Yaël Grosjean, CNRS Research Director
Team Members
Permanent Positions :
- Gérard MANIERE, UBE Professor
- Olivier LAMOTTE, CNRS Researcher
- Marco PAOLI, CNRS Tenure-Track Junior-Professor Chair
- Dehbia ABED-VIEILLARD, UBE Assistant Professor
- Georges ALVES, UBE Assistant Professor
- Christelle LEMAITRE-GUILLIER, CNRS Biological Research-Engineer
- Martine BERTHELOT-GROSJEAN, CNRS Biological Engineer
- Sylvie CHAUDY, CNRS Technician in Biology
- Amandine CHLEMAIRE, UBE Technician in Biology
- Serge LOQUIN, UBE Technician in Biology
Non Permanent Positions : post-doctoral fellows, PhD students, Short-term contrats :
- Justin FLAVEN-POUCHON, UBE Temporary Teaching and Research Assistant Professor ("ATER")
- Julie VITTET, PhD Student
- Julie EBERT, Master Student
Alumni
- Ziegler AB, PHD, Currently Junior-Group Leader at the Institute for Behavior- and Neuroscience, Münster University, Germany
- Depetris-Chauvin A, PhD, Currently Research Coordinator and Science writer at the Leibniz Institute
- Galagovsky D, PhD, Currently post-doc at Max Planck ICE
- Simonnet M, PhD, Currently ResearchCoordinator/ Scientific Researcher at ENALEES
- Geillon Flore, PdD, Currently CEO at Le Champ des Sourires
- Delescluse Julie, PhD, Currently post-doctoral fellow at LBBE in Lyon, France
Representative publications
Delescluse J, Simonnet MM, Ziegler AB, Piffaretti K, Alves G, Grosjean Y & Maniere G (2024). A LAT1-Like Amino-Acid Transporter Regulates Neuronal Activity in the Drosophila Mushroom Bodies. Cells, 13(6):1340. doi: 103390/cells13161340.
Montanari M, Manière G, Berthelot-Grosjean M, Dusabyinema Y, Gillet B, Grosjean Y, Kurz CL & Royet J (2024). Larval microbiota primes the Drosophila adult gustatory response. Nat Commun, 15(1):1341. doi: 10.1038/s41467-024-45532-4.
Cavey M, Charroux B, Travaillard S, Manière G, Berthelot-Grosjean M, Quitard S, Minervino C, Detailleur B, Grosjean Y & Prud'homme B (2023). Increased sugar valuation contributes to the evolutionary shift in egg-laying behavior of the fruit pest Drosophila suzukii. PLoS Biology, 21(12):e3002432. doi: 10.1371/journal.pbio.3002432.
Masuzzo A*, Manière G*, Grosjean Y§, Kurz L§ & Royet J§ (2022). Bacteria-Derived Peptidoglycan Triggers a Noncanonical Nuclear Factor-kB-Dependent Response in Drosophila Gustatory Neurons. Journal of Neuroscience, 42, 7809-7823. doi: 10.1523/JNEUROSCI.2437-21.2022.
Manière G§, Alves G, Berthelot-Grosjean M & Grosjean Y§ (2020). Growth regulation by amino acid transporters in Drosophila larvae. Cell Mol Life Sci, 77:4289-97. doi: 10.1007/s00018-020-03535-6.
Masuzzo A, Manière G, Viallat-Lieutaud A, Avazeri E, Zugasti O, Grosjean Y, Kurz CL & Royet J (2019). Peptidoglycan-dependent NF-κB activation in a small subset of brain octopaminergic neurons controls female oviposition. Elife, 8 pii: e50559. doi: 10.7554/eLife.50559.
Aboudhiaf S, Alves G, Parrot S, Amri M, Simonnet MM, Grosjean Y, Manière G§ & Seugnet L§ (2018). LAT1-like transporters regulate dopaminergic transmission and sleep in Drosophila. Sleep, 41. doi: 10.1093/sleep/zsy137.
Galagovsky D, Depetris-Chauvin A, Manière G, Geillon F, Berthelot-Grosjean M, Noirot E, Alves G & Grosjean Y (2018). Sobremesa L-type Amino Acid Transporter Expressed in Glia Is Essential for Proper Timing of Development and Brain Growth. Cell Reports, 24: 3156-3166. doi: 10.1016/j.celrep.2018.08.067.
Depetris-Chauvin A, Galagovsky D, Chevalier C, Maniere G & Grosjean Y (2017). Olfactory detection of a bacterial short-chain fatty acid acts as an orexigenic signal in Drosophila melanogaster larvae. Scientific Reports, 7:14230. doi: 10.1038/s41598-017-14589-1.
Manière G*, Ziegler AB*, Geillon F, Featherstone DE & Grosjean Y (2016). Direct Sensing of Nutrients via a LAT1-like Transporter in Drosophila Insulin-Producing Cells. Cell Reports, 17: 137-48. doi: 10.1016/j.celrep.2016.08.093.
Grosjean Y, Rytz R, Farine JP, Abuin L, Cortot J, Jefferis GSXE & Benton R (2011). An olfactory receptor for food-derived odours promotes male courtship in Drosophila. Nature 478, 236-40. doi: 10.1038/nature10428 .
*Co-first authorship
§Co-corresponding authors