Yaël GROSJEAN

Scientist
Yaël GROSJEAN

Informations

Researcher

PERSING – Sensory Perception, Neuron/Glie Interactions

Job

Research Director, CNRS

Team PERSING leader

Degree (Diploma)

2014: "Habilitation à Diriger les Recherches", University of Burgundy, Dijon, France

2002: PhD in Biochemistry, and Molecular and Cellular Biology

Activities

Research theme
Yaël Grosjean is a neurobiologist who was awarded the CNRS bronze medal in 2012. He uses Drosophila melanogaster as an experimental subject to study molecular and cellular pathways involving food odors and tastes to control brain function and behavioral outcomes. Grosjean defended his Ph.D. in 2002, where he studied the role of prospero in the nervous system to regulate male courtship. After working in J.-F. Ferveur’s lab (Dijon) and in R. Stocker’s lab (Fribourg), he joined D. Featherstone's laboratory at the University of Illinois at Chicago in 2004 to study the role of genderblind in the control of synaptic excitability and courtship behavior. In 2007, he joined R. Benton's lab in Lausanne to study olfaction through the role of inotropic receptors in the control of male courtship. Grosjean joined the CNRS in 2010 and was promoted to research director in 2017. Thanks to several grants, including one from the European Research Council, he established his team in Dijon at the CSGA. His work has been published in several prestigious scientific journals such as Nature, Nature Neuroscience, Nature Communications, and lead to an international patent (Drosomous). He is an expert for the European Council, and several funding schemes and scientific journals.
Scientific approach
Cellular Biology, Molecular Biology, biochemistry, genetics, in-vivo Cellular Imaging, Chemosensory Behavior, drosophila
Supervision
I have supervised numerous students, including several doctoral candidates and post-doctorals who have successfully transitioned into academic or economic world.
  • 2012 CNRS Bronze medal
  • 2012-2017 "Glifsco" ERC grant
  • 2010-2012 ANR-JCJC GGCB-2010
  • 2007 post-doctoral fellowship (to initiate a return to France)
  • 2002-2003 PhD ending "Bourse ARC" 
  • 1999-2002 MENRT (ministerial) PdD fellowship 
  • 1998  DEA (=Master II) fellowship from the Burgundy Council 
  • 1997 training period in a foreign country (UK) fellowship from the Burgundy Council

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Skills

Neurobiology, neurogenetics, olfaction, taste, glia, Amino-Acids transporters, food, Short-Chain Fatty-Acids, Courtship behavior, Drosophila

Publications

Montanari M., Manière G., Berthelot-Grosjean M., Dusabyinema Y., Gillet B., Grosjean Y., Kurz C.L. & Royet J. (2024) Larval microbiota primes the Drosophila adult gustatory response. Nat Commun, 15(1):1341. doi: 10.1038/s41467-024-45532-4.

Cavey M., Charroux B., Travaillard S., Manière G., Berthelot-Grosjean M., Quitard S., Minervino C., Detailleur B., Grosjean Y. & Prud'homme B. (2023) Increased sugar valuation contributes to the evolutionary shift in egg-laying behavior of the fruit pest Drosophila suzukii. PLoS Biology, 21(12):e3002432. doi: 10.1371/journal.pbio.3002432.

Masuzzo A., Manière G., Viallat-Lieutaud A., Avazeri E., Zugasti O., Grosjean Y., Kurz C.L. & Royet J. (2019) Peptidoglycan-dependent NF-κB activation in a small subset of brain octopaminergic neurons controls female oviposition. Elife, 8 pii: e50559. doi: 10.7554/eLife.50559.

Galagovsky D, Depetris-Chauvin A, Manière G, Geillon F, Berthelot-Grosjean M, Noirot E, Alves G & Grosjean Y. (2018) Sobremesa L-type Amino Acid Transporter Expressed in Glia Is Essential for Proper Timing of Development and Brain Growth. Cell Reports, 24: 3156-3166. doi: 10.1016/j.celrep.2018.08.067.

Manière G.*, Ziegler A.B.*, Geillon F., Featherstone D.E. & Grosjean Y. (2016) Direct Sensing of Nutrients via a LAT1-like Transporter in Drosophila Insulin-Producing Cells. Cell Reports, 17: 137-48. doi: 10.1016/j.celrep.2016.08.093.

Grosjean Y., Rytz R, Farine J.P., Abuin L., Cortot J., Jefferis G.S.X.E. & Benton R. (2011) An olfactory receptor for food-derived odours promotes male courtship in Drosophila. Nature 478, 236-40. doi: 10.1038/nature10428.

Silbering A.S.*, Rytz R.*, Grosjean Y.*, Abuin L., Ramdya P., Jefferis G.S.X.E. & Benton R. (2011) Functional neuroarchitecture and evolution of the Drosophila olfactory subsystems. Journal of Neuroscience 31, 13376-13385. doi: 10.1523/JNEUROSCI.2360-11.2011.

Ai M.*, Min S.*, Grosjean Y., Leblanc C., Bell R., Benton R. & Suh GS. (2010) Acid sensing by the Drosophila olfactory system. Nature 468, 691-695. doi: 10.1038/nature09537.

Grosjean Y., Grillet M., Augustin H., Ferveur J.-F. & Featherstone D.E. (2008) A glial amino-acid transporter controls synapse strength and courtship in Drosophila. Nature Neuroscience 11, 54-61. doi: 10.1038/nn2019.

Augustin H.*, Grosjean Y.*, Chen K., Sheng Q. & Featherstone D.E. (2007) Nonvesicular release of glutamate by glial xCT transporters suppresses glutamate receptor clustering in vivo. Journal of Neuroscience, 27, 111-123. *Co-premiers auteurs. doi: 10.1523/JNEUROSCI.4770-06.2007.

PERSING – Sensory Perception, Neuron/Glie Interactions