Marco PAOLI

marco.paoli@u-bourgogne.fr

 marc.paoli@gmail.com

 HAL

 ORCID

CNRS Tenure-Track Junior Professor Chair

2010: PhD in Bioscience - Cell Biology, University of Padova, Italy

How does the brain perceive sensory inputs and integrate them with internal states to drive appropriate behavioral responses?

I investigate this fundamental question through the invertebrate olfactory system, focusing on the domestic honey bee, Apis mellifera. Honey bees are a renowned model for studying olfactory learning, memory formation, and sensory coding. With their relatively simple yet highly efficient brains, they provide a tractable system for investigating the neural representation of olfactory stimuli and how these representations dynamically changes during time and upon appetitive or aversive learning.

My research combines diverse approaches, including behavioral analysis, movement tracking, in vivo functional calcium imaging, neuroanatomy, pharmacology, and neural network modeling. Together, these tools allow me to explore the neuronal mechanisms underlying olfactory perception and learning, shedding light on how sensory information is encoded by the brain and guides behavior.

Insect neuroscience, honey bee, calcium imaging, olfaction, sensory coding

Paoli M, Wystrach A, Ronsin B, Giurfa M (2024). Analysis of fast calcium dynamics of honey bee olfactory coding. eLife, 13:RP93789. https://doi.org/10.7554/eLife.93789.3 

Paoli M, Antonacci Y, Albi A, Faes L, Haase A (2023). Granger Causality analysis of transient calcium dynamics in the honey bee antennal lobe network. Insects, 14(6), 539. https://doi.org/10.3390/insects14060539 

Paoli M, Macri C, Giurfa M (2023). A cognitive account of trace conditioning in insects. Current Opinion in Insect Science, 101034. https://doi.org/10.1016/j.cois.2023.101034 

Bestea L, Paoli M, Arrufat P, Ronsin B, Carcaud J, Sandoz J-C, Velarde R, Giurfa M, de Brito Sanchez MG (2022). The short neuropeptide F regulates appetitive but not aversive responsiveness in a social insect. iScience, 25(1): 103619. https://doi.org/10.1016/j.isci.2021.103619 

Paoli M, Galizia GC (2021). Olfactory coding in honeybee. Cell Tissue Research, 383(1):35-58. DOI: 10.1007/s00441-020-03385-5

Paoli M, Hiroshi N, Couzin-Fuchs E, Galizia GC (2020). Coding of odour and space in the hemimetabolous insect Periplaneta americana. J of Exp Biol, 2020:jeb,210832. https://doi.org/10.1242/jeb.218032 

Paoli M, Albi A, Zanon M, Zanini D, Antolini R, Haase A (2018). Neuronal response latencies encode first odor identity information across subjects. J. Neurosci, 38 (43), 9240-9251. DOI: 10.1523/JNEUROSCI.0453-18.2018  

Nishino H, Iwasaki M, Paoli M, Kamimura I, Yoritsune A, Mizunami M (2018). Spatial receptive fields for odor localization. Current Biology, 28, 600–608. DOI: 10.1016/j.cub.2017.12.055

Paoli M, Münch D, Haase A, Skoulakis E, Turin L, Galizia GC (2017). Minute impurities contribute significantly to olfactory receptor ligand studies: tales from testing the vibration theory. eNeuro, 0070-17.2017. DOI: 10.1523/ENEURO.0070-17.2017