Marie-Agnès BRINGER
Researcher
marie-agnes.bringer@inrae.fr
Position
Research Scientist, INRAE
- PhD Microbiology - Auvergne University, Clermont-Ferrand, France
Activities
Research theme
Marie-Agnès Bringer studies the influence of diet (e.g. nature and proportion of dietary fatty acids, fermentable fiber supplements, intermittent fasting) on retinal health during aging, considering an important link in the food-health chain: the gut microbiota.
Her research focuses on:
1- the dialogue between the gut and the retina, and the involvement of the gut microbiota in the development of age-related retinopathies such as age-related macular degeneration (AMD)
2- the potential of innovative dietary strategies targeting the dialogue between the gut and the retina to prevent certain alterations of retinal homeostasis (e.g. omega-3 fatty acid deficiency, decline in the functionality of the autophagy mechanism) associated with physiological and/or pathophysiological aging of the retina.
Supervision
Undergraduate and PhD students supervision
Aknowledgements
Key words
Retina, diet, lipids, autophagy, gut microbiota, gut-retina dialogue, probiotics, aging
Key Publications
- Lapaquette P, Terrat S, Proukhnitzky L, Martine L, Grégoire S, Buteau B, Cabaret S, Rieu A, Bermúdez-Humarán LG, Gabrielle PH, Creuzot-Garcher C, Berdeaux O, Acar N, Bringer MA. Long-term intake of Lactobacillus helveticus enhances bioavailability of omega-3 fatty acids in the mouse retina. NPJ Biofilms Microbiomes. 2024 Jan 18;10(1):4. doi: 10.1038/s41522-023-00474-5.
- Lapaquette P, Boucard AS, Chain F, Grégoire S, Bermúdez-Humarán LG, Acar N, Bringer MA. Time-Restricted Feeding Potentiates the Ability of Lacticaseibacillus casei to Enrich the Retina in Omega-3 Fatty Acids. Aging Dis. 2023 Dec 1;14(6):1945-1949. doi: 10.14336/AD.2023.0324.
- Bizeau JB, Albouery M, Grégoire S, Buteau B, Martine L, Crépin M, Bron AM, Berdeaux O, Acar N, Chassaing B, Bringer MA. Dietary Inulin Supplementation Affects Specific Plasmalogen Species in the Brain. Nutrients. 2022 Jul 28;14(15):3097. doi: 10.3390/nu14153097.
- Bringer MA, Gabrielle PH, Bron AM, Creuzot-Garcher C, Acar N. The gut microbiota in retinal diseases. Exp Eye Res. 2022 Jan;214:108867. doi: 10.1016/j.exer.2021.108867.
- Lapaquette P, Bizeau JB, Acar N, Bringer MA. Reciprocal interactions between gut microbiota and autophagy. World J Gastroenterol. 2021 Dec 28;27(48):8283-8301. doi: 10.3748/wjg.v27.i48.8283.
- Albouery M, Bretin A, Buteau B, Grégoire S, Martine L, Gambert S, Bron AM, Acar N, Chassaing B, Bringer MA. Soluble Fiber Inulin Consumption Limits Alterations of the Gut Microbiota and Hepatic Fatty Acid Metabolism Caused by High-Fat Diet. Nutrients. 2021 Mar 23;13(3):1037. doi: 10.3390/nu13031037.
- Albouery M, Buteau B, Grégoire S, Martine L, Gambert S, Bron AM, Acar N, Chassaing B, Bringer MA. Impact of a high-fat diet on the fatty acid composition of the retina. Exp Eye Res. 2020 Jul;196:108059. doi: 10.1016/j.exer.2020.108059.
- Munia I, Gafray L, Bringer MA, Goldschmidt P, Proukhnitzky L, Jacquemot N, Cercy C, Ramchani Ben Otman K, Errera MH, Ranchon-Cole I. Cytoprotective Effects of Natural Highly Bio-Available Vegetable Derivatives on Human-Derived Retinal Cells. Nutrients. 2020 Mar 24;12(3):879. doi: 10.3390/nu12030879.
- Albouery M, Buteau B, Grégoire S, Cherbuy C, Pais de Barros JP, Martine L, Chain F, Cabaret S, Berdeaux O, Bron AM, Acar N, Langella P, Bringer MA. Age-Related Changes in the Gut Microbiota Modify Brain Lipid Composition. Front Cell Infect Microbiol. 2020 Jan 14;9:444. doi: 10.3389/fcimb.2019.00444.