Eye & Nutrition Group
Research
The retina is a lipid rich tissue and the role of those lipids is increasingly proven to be paramount for its structure and its homeostasis
In this context, the Eye & Nutrition team pursues several objectives:
1. Understand the role of lipids and their metabolism in the physiology of the retina and its dysfunctions.
With solid expertise in lipid analysis, we particularly focus our research on omega-3 polyunsaturated fatty acids, cholesterol and oxysterols, plasmalogens and gangliosides. We are particularly interested in the processes of angiogenesis, autophagy, neurodegeneration as well as neuron-glia interactions
2. Act upon the factors influencing retinal homeostasis, especially the bioavailability of lipids.
We strive to determine the influence of diet on the lipid content of the retina and the consequences of unbalanced diets on its development, function and aging. We also seek to optimize retinal lipid content through different interventions, in particular dietary intake, but also through innovative strategies targeting the intestinal microbiota or through nutrient vectorization approaches.
To do this, we implement various experimental models: cultured cells, rodent models, human subjects.
Our approach is translational. The association of researchers and clinicians allows for a cross-fertilization of interests, objectives and projects, generating results that are both important for fundamental research and potentially leading to clinical applications.
The Eye & Nutrition team actively takes part in the dissemination of the knowledge it produces: to academia of course, in the fields of ophthalmology, lipids and nutrition but also to ophthalmologists, to the pharmaceutical industry, to patient associations and more broadly to the general public.
Key words
Retina, diet, lipids, autophagy, intestinal microbiota, gut-retina cross talk, probiotics, aging, Gangliosides, Cholesterol, Oxysterols, Neuron-glia interaction, Glaucoma, Lipidomics, Milk, Perinatal nutrition
Team
Team leaders
Niyazi ACAR, PhD- Senior Researcher
Catherine CREUZOT GARCHER, MD - Senior Consultant/Clinical Lecturer, Head of Ophtalmology Dpt - Dijon University Hospital 
Team members
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Key Publications
Lapaquette P, Terrat S, Proukhnitzky L, Martine L, Grégoire S, Buteau B, Cabaret S, Rieu A, Bermúdez-Humarán LG, Gabrielle PH, Creuzot-Garcher C, Berdeaux O, Acar N, Bringer MA (2024). Long-term intake of Lactobacillus helveticus enhances bioavailability of omega-3 fatty acids in the mouse retina. NPJ Biofilms Microbiomes, 10(1):4. doi: 10.1038/s41522-023-00474-5.
Bizeau JB, Albouery M, Grégoire S, Buteau B, Martine L, Crépin M, Bron AM, Berdeaux O, Acar N, Chassaing B, Bringer MA (2022). Dietary Inulin Supplementation Affects Specific Plasmalogen Species in the Brain.
Nutrients, 14(15):3097. doi: 10.3390/nu14153097.
Karadayi R, Pallot C, Cabaret S, Mazzocco J, Gabrielle PH, Semama DS, Chantegret C, Ternoy N, Martin D, Donier A, Gregoire S, Creuzot-Garcher CP, Bron AM, Bretillon L, Berdeaux O, Acar N (2022). Modification of erythrocyte membrane phospholipid composition in preterm newborns with retinopathy of prematurity: The omegaROP study. Front Cell Dev Biol, 10:921691. doi: 10.3389/fcell.2022.921691.
Acar N, Merle BMJ, Ajana S, He Z, Grégoire S, Hejblum BP, Martine L, Buaud B, Bron AM, Creuzot-Garcher CP, Korobelnik JF, Berdeaux O, Jacqmin-Gadda H, Bretillon L, Delcourt C; Biomarkers of Lipid Status And metabolism in Retinal ageing (BLISAR) Study Group (2021). Predicting the retinal content in omega-3 fatty acids for age-related macular-degeneration. Clin Transl Med., 11(7):e404. doi: 10.1002/ctm2.404
Albouery M, Buteau B, Grégoire S, Martine L, Gambert S, Bron AM, Acar N, Chassaing B, Bringer MA (2020). Impact of a high-fat diet on the fatty acid composition of the retina. Exp Eye Res., 196:108059. doi: 10.1016/j.exer.2020.108059.
Vidal E, Jun B, Gordon WC, Maire MA, Martine L, Grégoire S, Khoury S, Cabaret S, Berdeaux O, Acar N, Bretillon L, Bazan NG (2020). Bioavailability and spatial distribution of fatty acids in the rat retina after dietary omega-3 supplementation. J Lipid Res., 61(12):1733-1746. doi: 10.1194/jlr.RA120001057.
Léger-Charnay E, Masson EAY, Morala T, Martine L, Buteau B, Leclere L, Bretillon L, Gambert S (2019). Is 24(S)-hydroxycholesterol a potent modulator of cholesterol metabolism in Müller cells? An in vitro study about neuron to glia communication in the retina. Exp Eye Res., 189:107857. doi: 10.1016/j.exer.2019.107857
Gabrielle PH, Seydou A, Arnould L, Acar N, Devilliers H, Baudin F, Ben Ghezala I, Binquet C, Bron AM, Creuzot-Garcher C (2019). Subretinal Drusenoid Deposits in the Elderly in a Population-Based Study (the Montrachet Study). Invest Ophthalmol Vis Sci., 60(14):4838-4848. doi: 10.1167/iovs.19-27283.
Colijn JM, Buitendijk GHS, Prokofyeva E, Alves D, Cachulo ML, Khawaja AP, Cougnard-Gregoire A, Merle BMJ, Korb C, Erke MG, Bron A, Anastasopoulos E, Meester-Smoor MA, Segato T, Piermarocchi S, de Jong PTVM, Vingerling JR, Topouzis F, Creuzot-Garcher C, Bertelsen G, Pfeiffer N, Fletcher AE, Foster PJ, Silva R, Korobelnik JF, Delcourt C, Klaver CCW; EYE-RISK consortium; European Eye Epidemiology (E3) consortium (2017) Prevalence of Age-Related Macular Degeneration in Europe: The Past and the Future. Ophthalmology.124(12):1753-1763. doi: 10.1016/j.ophtha.2017.05.035.
Sibille E, Berdeaux O, Martine L, Bron AM, Creuzot-Garcher CP, He Z, Thuret G, Bretillon L, Masson EA (2016). Ganglioside Profiling of the Human Retina: Comparison with Other Ocular Structures, Brain and Plasma Reveals Tissue Specificities. PLoS One., 11(12):e0168794. doi: 10.1371/journal.pone.0168794.
