Sandrine Chometton
General information
Researcher
SuPeR (Sugars - Perception and Receptors)
sandrine.chometton@inrae.fr
CV HAL
Job
PhD, INRAE Tenure-Track Junior Professor Chair
- Post-Doctorate (2019-2023), University of Southern California (USC), Los Angeles CA, USA
- Post-Doctorate (2016-2019), Laval University, Quebec City QC, Canada
- PhD (2015), E2SNC laboratory, Besançon, France
Activities
Research theme
After obtaining her PhD in 2015 (University of Franche-Comté, Besançon), titled the morphofunctional organization of the posterior lateral hypothalamus in rodent, Sandrine completed a first post-doctoral fellowship from 2016 to 2019 at Laval University in Quebec City, Canada. She worked on the neurobiological basis of eating disorders, focusing on the reward circuit and the Relaxin-3 / RXFP3 system. She then continued with a second post-doctoral position from 2019 to 2023 at USC (University of Southern California) in Los Angeles, USA. Sandrine's work has focused on the detection of glucose by the taste system, as well as the study of the role of the hypothalamus in the specific appetite for glucose. Sandrine joined the CSGA on november 2023 on an INRAE Junior Professor Chair. She aims to understand the molecular mechanisms, whether or not dependent on taste receptors, involved in the perception of different sweet compounds in the taste system and in the brain, as well as the sensory and metabolic interactions that underlie food choice and appetite in the rodent model.
Scientific approach
Behavior, molecular biology, histology
Supervision
PhD students:
- Savanah Buiret, 2024-2027
Undergraduate students:
- Matéo Teixeira, 2024
Aknowledgements
- 2023 : Rewarded at the tenure-track junior professor position of the INRAE Human Nutrition and Food Safety division.
- 2020 : Winner of the Ethan Sims Young Investigator Award during the ObesityWeek of the Obesity Society.
- 2011 : Rewarded at the ES doctoral school PhD fellowship.
Key words
Taste system, glucose, hypothalamus, metabolism, sweeteners, obesity / diabetes
Important publications
- Chometton S, Tsan L, Hayes AMR, Kanoski SE, Schier LA (2023). Early-life influences of low-calorie sweetener consumption on sugar taste. Physiol Behav. 264:114133. doi: 10.1016/j.physbeh.2023. 114133.
- Tsan L, Chometton S, Hayes AM, Klug ME, Zuo Y, Sun S, Bridi L, Lan R, Fodor AA, Noble EE, Yang X, Kanoski SE, Schier LA (2022). Early-life low-calorie sweetener consumption disrupts glucose regulation, sugar-motivated behavior, and memory function in rats. JCI Insight. 24;7(20):e157714. doi: 10.1172/jci.insight.157714.
- Chometton S, Jung AH, Mai L, Dal Bon T, Ramirez AO, Pittman DW, Schier LA (2022). A glucokinase-linked sensor in the taste system contributes to glucose appetite. Mol Metab. 64:101554. doi: 10.1016/ j.molmet.2022.
- Chometton S, Guèvremont G, Seigneur J, Timofeeva E, Timofeev I (2020). Projections from the nucleus accumbens shell to the ventral pallidum are involved in the control of sucrose intake in adult female rats. Brain Struct Funct. 225(9):2815-2839. doi: 10.1007/s00429-020-02161-z.
- Barbier M, Chometton S, Pautrat A, Miguet-Alfonsi C, Datiche F, Gascuel J, Fellmann D, Peterschmitt Y, Coizet V, Risold PY (2020). A basal ganglia-like cortical-amygdalar-hypothalamic network mediates feeding behavior. Proc Natl Acad Sci U S A. 117(27):15967-15976. doi: 10.1073/pnas.2004914117.
- Chometton S, Charrière K, Bayer L, Houdayer C, Franchi G, Poncet F, Fellmann D, Risold PY (2017). The rostromedial zona incerta is involved in attentional processes while adjacent LHA responds to arousal: c-Fos and anatomical evidence. Brain Struct Funct. 222(6):2507-2525. doi: 10.1007/s00429-016-1353-3.
- Chometton S, Pedron S, Peterschmitt Y, Van Waes V, Fellmann D, Risold PY (2016). A premammillary lateral hypothalamic nuclear complex responds to hedonic but not aversive tastes in the male rat. Brain Struct Funct. 221(4):2183-208. doi: 10.1007/s00429-015-1038-3