Anne-Claire Mitaine-Offer
General information
Researcher
SuPeR (Sugars - Perception and Receptors)
anne-claire.offer@u-bourgogne.fr
Orcid
Job
PhD, UBE Full Professor
- PhD in Pharmacognosy, University of Reims Champagne-Ardenne
- State Diploma of Doctor of Pharmacy, University of Montpellier
Activities
Research theme
The main research theme focuses on glycosylated natural secondary metabolites, such as saponins. After extraction (microwave, ultrasound), then purification by various chromatographic protocols, their structure is analyzed mainly by spectroscopic methods (2D NMR, MS). Once their structure is determined, their activity is evaluated on the sweet-tasting TAS1R2/TAS1R3 receptors to establish structure/activity relationships.
Teaching
- Lectures in Pharmacognosy, Phytotherapy, and Aromatherapy
- Responsible of the University Diploma in Aromatherapy
Responsability
Co-direction of the team SuPeR
Key words
Phytochemistry, Chemistry of natural compounds, glycosides, chromatography, structural analysis, 2D-NMR, structure/activity relationships
Important publications
- Pertuit D, Sautour M, Miyamoto T, Delaude C, Kapundu M, Lacaille-Dubois MA, Mitaine-Offer AC (2024). Oleanolic acid glycosides from two species of Olax : Olax wildemanii and Olax subscorpioidea, Phytochemistry Letters, 2024, 60, 14-18.
- Nazaryan S, Bruguière A, Hovhannisyan N, Miyamoto T, Dias AMM, Bellaye PS, Collin B, Briand L, Mitaine-Offer AC, (2023). Oleanolic Acid Glycosides from Scabiosa caucasica and Scabiosa ochroleuca: Structural Analysis and Cytotoxicity, Molecules, 28, 4329.
- Hobloss S, Bruguière A, Pertuit D, Miyamoto T, Tanaka C, Belloir C, Lacaille-Dubois MA, Briand Loïc, Mitaine-Offer AC (2022). Activation of a Sweet Taste Receptor by Oleanane-Type Glycosides from Wisteria sinensis. Molecules, 27, 7866.
- Pertuit D, Mitaine-Offer AC, Miyamoto T, Tanaka C, Delaude C, Bellaye PS, Collin B, Lacaille-Dubois MA, (2022). Oleanane-type glycosides isolated from the trunk barks of the Central African tree Millettia laurentii. Fitoterapia, 159, 105193.
- Pertuit D, Mitaine-Offer AC, Miyamoto T, Tanaka C, Belloir C, Briand L, Lacaille-Dubois MA, (2021). Triterpenoid saponins from the cultivar “green elf” of Pittosporum tenuifolium. Molecules, 26, 6805