Stéphane Fraichard (PhD)

Scientist
Stéphane Fraichard

General information

ITA

TPI – Taste and Post-ingestive Integration

 Stephane.fraichard@u-bourgogne.fr
 https://cv.hal.science/stephane-fraichard

Job

UBE, Researcher

PhD biochemistry, cellular and molecular biology, University of Burgundy, France

Activities

Research theme
Stéphane's primary focus is studying the effect of sweet taste on energy uncoupling and its impact on feeding behavior and metabolism in Drosophila. He expertly utilizes various tools, including molecular biology (molecular engineering, qPCR, RNAseq…), protein biochemistry, genetics (CrispR Cas9), gustatory electrophysiology, and behavioral tests (PER, Flypad) to accomplish this project. As a valuable member of the TPI team, Stéphane adeptly manages the molecular biology, radioactivity, and electrophysiology laboratories. With his extensive experience, he confidently supervises student trainees and has successfully co-directed two doctoral theses. Stéphane's expertise also extends to teaching molecular biology in the 3rd year of the Biological Engineering degree course in Medical Biology and Biotechnology at the Dijon IUT. Additionally, he serves as a highly respected expert on several ITRF recruitment juries.
Scientific approach
Behavior, molecular biology, genetic, electrophysiology
Supervision
Stéphane supervised numerous students including PhD students.
Key words
Taste, Sugars, Neurobiology, Molecular Biology, Genetics, Behavior, Drosophila

Important publications

  • Gonis E, Fraichard S, Chertemps T, Hecker A, Schwartz M, Canon F, Neiers F (2022). Expression Patterns of Drosophila Melanogaster Glutathione Transferases. Insects, 13(7), 612. https://doi.org/10.3390/insects13070612. ⟨hal-03728127⟩
  • Fraichard S, Gonzalez D, Grassein P, Delarue P, Senet P, Nicolaï A, Chavanne E, Mucher E, Artur Y, Ferveur JF, Heydel JM, Briand L, Neiers F (2018). Data on the expression of GSTE1 and GSTE7 in Drosophila chemosensory organs after isothiocyanate exposure. Data in Brief, 20, 254‑257. https://doi.org/10.1016/j.dib.2018.07.062. ⟨hal-02498984⟩
  • Fraichard S, Legendre A, Lucas P, Chauvel I, Faure P, Neiers F, Artur Y, Briand L, Ferveur JF, Heydel JM (2020). Modulation of sex pheromone discrimination by a UDP-glycosyltransferase in Drosophila melanogaster. Genes, 11(3), 237. https://www.mdpi.com/2073-4425/11/3/237. ⟨hal-02498984⟩
  • Rihani K, Fraichard S, Chauvel I, Poirier N, Delompré T, Neiers F, Tanimura T, Ferveur JF, Briand L (2019). A conserved odorant binding protein is required for essential amino acid detection in Drosophila. Communications Biology, 2, 425. https://doi.org/10.1038/s42003-019-0673-2. ⟨hal-04524928⟩
  • Gonzalez, D., Fraichard, S., Grassein, P., Delarue, P., Senet, P., Nicolaï, A., Chavanne, E., Mucher, E., Artur, Y., Ferveur, J.-F., Heydel, J.-M., Briand, L., & Neiers, F. (2018). Characterization of a Drosophila glutathione transferase involved in isothiocyanate detoxification. Insect Biochemistry and Molecular Biology, 95, 33‑43. https://doi.org/10.1016/j.ibmb.2018.03.004. ⟨hal-02383021⟩
  • Houot, B., Cazalé-Debat, L., Fraichard, S., Everaerts, C., Saxena, N., Sane, S. P., & Ferveur, J.-F. (2018). Gene Regulation and Species-Specific Evolution of Free Flight Odor Tracking in Drosophila. Molecular Biology and Evolution, 35(1), 3‑15. https://doi.org/10.1093/molbev/msx241. ⟨hal-01702704⟩
  • Coelho, A., Fraichard, S., Le Goff, G., Faure, P., Artur, Y., Ferveur, J.-F., & Heydel, J.-M. (2015). Cytochrome P450-dependent metabolism of caffeine in Drosophila melanogaster. PloS One, 10(2), e0117328. https://doi.org/10.1371/journal.pone.0117328. ⟨hal-01212004⟩
  • Houot, B., Fraichard, S., Greenspan, R. J., & Ferveur, J.-F. (2012). Genes involved in sex pheromone discrimination in Drosophila melanogaster and their background-dependent effect. PloS One, 7(1), e30799. https://doi.org/10.1371/journal.pone.0030799. ⟨hal-00723260⟩
  • Fraichard, S., Bougé, A.-L., Kendall, T., Chauvel, I., Bouhin, H., & Bunch, T. A. (2010). Tenectin is a novel αPS2βPS integrin ligand required for wing morphogenesis and male genital looping in Drosophila. Developmental Biology, 340(2), 504‑517. https://doi.org/10.1016/j.ydbio.2010.02.008. ⟨hal-00761472⟩
  • Fraichard, S., Bouge, A.-L., Chauvel, I., & Bouhin, H. (2006). Tenectin, a novel extracellular matrix protein expressed during Drosophila melanogaster embryonic development. Gene Expression Patterns, 6(8), 772‑776. https://doi.org/10.1016/j.modgep.2006.01.007. ⟨hal-00451229⟩

TPI – Taste and Post-ingestive Integration